Learn about nodular lymphocyte-predominant Hodgkin lymphoma and find resources recommended by GLOW patient advocates.
Hodgkin lymphoma can be divided into two main types: nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and classic Hodgkin lymphoma (cHL). While much is known about cHL, there is no known cause of NLPHL and there is a lot that is yet to be learned about it.
Researchers currently understand that NLPHL…
GLOW collaborators have published an analysis of recent research and advancements in the understanding of NLPHL biology, risk stratification, and treatment in November 2024, which provides an overview of the latest data and treatment approaches.
NLPHL Fact Sheets
More information about NLPHL and how it is diagnosed, staged, and treated can be found at the links below:
Lymphocyte-Predominant International Prognostic Score (LP-IPS)
The Lymphocyte-Predominant International Prognostic Score (LP-IPS) is a validated risk stratification tool created by GLOW. The LP-IPS is meant to be used together with diagnosis and staging information to understand a patient’s risk level and whether or not less aggressive (also called de-intensified or de-escalated) treatment may be appropriate.
The LPS-IPS is calculated using 4 known factors that are related to survival and/or to transformation to aggressive lymphoma. The LP-IPS assigns one risk point each for:
A score of 3-4 indicates that a patient has high risk NLPHL. Approximately 2.7% of NLPHL diagnoses are categorized as high risk when using the LP-IPS.
NLPHL has had several names over the years as researchers have learned more about how to best classify types of lymphoma. Below is a list of alternative names for NLPHL that you may see:
There is still debate among lymphoma researchers about how to classify NLPHL. NLPHL and NLPBL are the two terms currently utilized by the international scientific community.
GLOW uses the term NLPHL based on its pathology and current scientific understanding.
There are several organizations around the world that provide informational, financial, clinical trials identification, and peer support for patients with NLPHL, their caregivers, and their families. Below are a few tips and resources if you are seeking support.
Tips
Lymphoma Support Groups
Many cancer support organizations provide support for patients with NLPHL. Below are a few lymphoma-specific support organizations that provide extensive patient and caregiver support to patients worldwide.
Lymphoma Research Foundation (LRF)
LRF hosts a variety of in-person, remote, and written learning opportunities for patients, caregivers, and family members. Several resources are available in multiple languages. GLOW partners with LRF to provide NLPHL expertise, including LRF’s Hodgkin lymphoma fact sheet, which is reviewed and updated annually by GLOW NLPHL experts.
Website: https://www.lymphoma.org/ (Sign up for event and fact sheet updates via the form at the bottom of the home page!)
LRF resources: https://lymphoma.org/resources/
LRF helpline:helpline@lymphoma.org
Leukemia and Lymphoma Society (LLS)
LLS maintains an extensive Hodgkin lymphoma booklet for patients and caregivers that is reviewed by a lymphoma specialist.
Website: https://www.lls.org/
LLS contact form: www.lls.org/form/contact-us
Lymphoma Action
Lymphoma action is based in the United Kingdom and has numerous resources for patients, caregivers, and family members.
Website: https://lymphoma-action.org.uk/
Lymphoma Australia
Lymphoma Australia provides resources for patients with lymphoma as well as educational opportunities for professionals.
Website: https://www.lymphoma.org.au/
Lymphoma Coalition
The Lymphoma Coalition maintains a database of lymphoma support organizations around the world.
Website: https://lymphomacoalition.org
Database of organizations: https://lymphomacoalition.org/member-organisation/
MyLymphomaTeam
MyLymphomaTeam is a social network for people living with lymphoma.
Website: https://www.mylymphomateam.com/
The Global nLPHL One Working Group is committed to improving outcomes for all patients diagnosed with nodular lymphocyte-predominant Hodgkin lymphoma.
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